In the following papers the students considered the history of biological and chemical warfare and also the agents which are used in biological and chemical warfare.
Miles Houser
Jennifer Hudson
HISTORY OF BIOLOGICAL AND CHEMICAL WARFARE Throughout history chemical and biological weaponry has been part of several civilization's arsenals. Of the two, biological warfare has been around for centuries, actually since before the birth of Christ. Even though the beginning stages of biological weaponry was rather primitive, it was still very effective and lethal. Throughout this paper you will be privy to several examples of these awful substances as they appeared throughout the ages.
Most people believe that biological warfare began sometime during World War I, but this is not the case. In fact, some time around 400 B.C., the Ancient Roman Empire began to use biological warfare. They utilized the simple idea of chucking dead animal carcasses into their enemy's water supply to contaminate it. This not only decreased their enemy's numbers, but lowered their morale as well. As time went on, the Romans obtained a new weapon, the catapult. At first, they would hurtle large stones and hard objects at their enemy's walls. Soon they returned to their idea of biological warfare and began adding dead soldiers, livestock, and manure to their arsenal. This way they infected their enemies with numerous diseases and viruses. Through the next few civilizations very few, if any, new innovations of this tactic were created.
The Middle Ages was a time of upheaval. The Golden Horde of Mongolia was the raging, blood thirsty superpower of the time. Under the leadership of Ghangis Khan, the Mongol Horde whirled across Europe, and into Russia, which they later conquered. However, unlike their predecessors, the Mongols did not use dysentery, Salmonella, E-coli, etc... They used something much more deadly and contagious. They launched corpses infected with the bubonic plague. Many historians actually even believe that this was a significant mechanism for transmission of the plague that killed over 25 million people in Medieval Europe. Over the next few centuries, not one country or civilization came close to the massive slaughter the Tartars accomplished.
In the history of humanity there have been countless acts of genocide. Whether justification involves skin color, race, religion, gender, or just paranoia; there have been groups of people that have been senselessly massacred. Biological weaponry just happened to be the most cost effective and reliable method. In 1754, France and England went to war in North America. The Native American population fought on both sides during this war. The British suspected the Indians of secretly working for the French and giving them sensitive British information. As an "act of goodwill", the British sent the Indians a shipment of blankets for the approaching winter. Unknown to the Indians was that these blankets had been used in a British hospital for smallpox victims. A surge of smallpox infected thousands of Native Americans, killing off a large percentage of their population. Obviously there is a myriad of historical acts of biological warfare that have not been listed above.
In 1918, biological warfare reared its ugly head yet again. It was the theory of the times that technology and science were the way to winning wars, and they were the most cost-effective as well. Japan was the pioneer on the biological front, and even created a special military unit (Unit 731) dedicated to only the research of biological weapons. As time progressed Japan expanded its territory, and took over Manchuria. After the takeover of Manchuria, Unit 731 moved in. Apparently this was because it was a secure location and had an endless supply of human test subjects. In 1941 they began crop dusting China with the bubonic plague. During World War II, they also used American POWs as test subjects. Sometime during 1942, the U.S. Government seized all information the Japanese had learned from these tests. With this information the U.S. began its own biological warfare program.
At the same time in the world, Great Britain, as well, was working on the development of biological weapons. However their program predominately specialized in Bacillus anthracis spores. They released the virus with a conventional bomb on Gruinard Island, off the coast of Scotland. The British government had believed that they were far enough off the coast that it would not permanently contaminate. They were wrong. They tried to decontaminate the island by setting all the brush and topsoil on fire to burn the organism up. This effort failed since they did not expect that anthrax spores could bury into the ground and remain viable for later infections.
The U.S. furiously worked on its biological weapons program throughout the Cold War. It made several attempts to secretly infect U.S. citizens with a group of several different agents in a span of twenty years. But the programs were shut down in 1969. In today's government and military branches there are research efforts to examine a myriad of new strains, not for offensive purposes, but to find ways to deal with them.
Chemical weapons and their discovery was a major turning point in war and battle strategies. In Germany in 1915, chlorine gas was used for the first time. This marvelous creation was invented by Professor Fritz Haber, who was known as the father of chemical warfare. Many people believe that the beginning of chemical warfare was "At 5 PM on 22 April 1915....." But it actually began the year prior to that. In 1914 the French military began using shells filled with ethyl bromoacetate. During the beginning of chemical warfare, many compounds were tested to see their toxic capabilities. Of the 21 listed compounds tested chlorine, phosgene, diphosgene, chloropicrin, hydrogen cyanide, cyanogen chloride, and mustard were used in mass quantities. During World War 1, countries were producing chemical weapons in the tons. Over 189,195 tons were produced. And along with this arsenal, new ways of delivering these agents came about. During the war, 1,296,853 people were killed by 125,000 tons of chemical weapons.
A variation of chemical weaponry, was discovered by Dr. Gerhard Schrader in 1936. He discovered nerve gases. He first created ethyl dimethylphosphoramidocyanidate,GA; or Tabun. He also created acyl acidssulfonyl fluorides, fluoroethanol deriviatives,fluoroacetic acid derivatives, and dimethylphosporamidofluoridic acids. Nerve gases were created because they were easily spread, and were very persistent in the environment. They can be absorbed through consumption, inhalation, or through skin contact. Several new compounds have been created such as Soman and VX.
Biological and chemical warfare has been an important part of battle plans and strategies for centuries. They have been used to win wars, solve conflicts, and ease people's fears, as well as create new ones. Human nature and the human condition continually allow groups to justify the use of these terrible weapons. No doubt, the future will offer many more challenges in this arena of warfare.
SPREADSHEET OF
BIOLOGICAL AGENTS
USED IN WARFARE
Biological weapons come in many different forms. They can be produced by plants and animals. Biological weapons also cause many different symptoms, ranging anywhere from headaches and nausea to death and they can even be used to influence the mind. Usually used in gas or liquid form, they can also be used in food and water poisoning. They are called "poor man's nuke" they are cheaper to manufacture and some would say just as lethal. Here are several biological agents used in biological warfare.
| Agent Name: Bacillus anthracis What Agent Causes: Anthrax Incubation Period: 1 to 6 days Length: 1 to 2 days Treatable: Yes Mortality Rate: 87% Dosage/Symptoms: In cases where 8,000 to 50,000 spores where tested the symptoms were as follows; fever and fatigue often followed by some improvement, then a quick severe case of resperatory problems, shock, pneumonia and then death. It is treatable if vaccine is administered before onset of symptoms. |
Agent Name: Yersinia Pestis What Agent Causes: Plague Incubation Period: 2 to 10 days Length: 1 to 2 days Treatable: Yes Mortality Rate: 50% if not treated 5% if treated Dosage/Symptoms: If exposed to 100 to 500 organisms one could expect to feel malaise, high fever, tender lymph nodes, skin lesions, possible hemorrages, circulatory failure and then death. It is treatable if antibiotics are administered within 24 hours of start of symptoms.
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| Agent Name: Brucella suis What Agent Causes: Brucellosis Incubation Period: 5 to 6 days Length: Unknown Treatable: Yes Mortality Rate: 2% Dosage/Symptoms: In cases where 100 to 1000 organisms where used symptoms were flu-like symptoms, including fever and chills, headache, appetite loss, mental depression, extreme fatigue, aching joints, sweating, probable gastrointestinal symptoms and possibly death. It is treatable with antibiotics but no vaccine has been found. |
Agent Name: Pasturella tularensis What Agent Causes: Tularemia (AKA rabbit fever or deer fly fever) Incubation Period: 1 to 10 days Length: 1 to 3 weeks Treatable: Yes Mortality Rate: 30% Dosage/Symptoms: In cases where a person is infected with 10 to 50 organisms the symptoms are fever, headache, malaise, general discomfort, irritating cough and weight loss. It is treatable but only if antibiotics are administered early. Vaccine is also available |
| Agent Name:Rickettsiae Coxiella burnetti What Agent Causes: Q-fever Incubation Period: 2 to 14 days Length: 2 to 14 days Treatable: Yes Mortality Rate: 1% Dosage/Symptoms: If 10 organisms are administered the symptoms include coughing, aches, fever, chest pain and pneumonia. It is treatable with antibiotics and a vaccine is also available. |
Agent Name: Variola virus What Agent Causes: Smallpox Incubation Period: 12 days Length: Several weeks Treatable: Yes Mortality Rate: 35% Dosage/Symptoms:if dasage is 10 to 100 organisms symptoms will be malaise, fever, vommiting, headache and lesions. Treatable only if vaccine is administered very quickly. Also there is only a small amount of vaccine available. |
| Agent Name: Venezuelan equine encephalitis virus What Agent Causes: Encephalitis Incubation Period: 1 to 5 days Length: 1 to 2 weeks Treatable: Yes Mortality Rate: Low Dosage/Symptoms: When the dosage is from 10 to 100 organisms the symptoms are a sudden onset of fever, seveare headache, muscle pain, nausea, vommiting, coughing, sore throat and diarrhea. No antibiotic therapy exists but a vaccine is available. |
Agent Name: Yellow fever virus What Agent Causes: Yellow fever Incubation Period: 3 to 6 days Length:1 to 2 weeks Treatable: Yes Mortality Rate: 5% Dosage/Symptoms: If dasage is 1 to 10 organisms the symptoms will be sever fevering, headache, couogh, nausea, vomitting, and vascular complications including easy bleeding and low blood pressure. No specific therapy |
| Agent Name: Botulinum toxin (created from Clostridium botulinum bacterium) What Agent Causes: Botulism Incubation Period: 24 to 36 hours Length:24 to 72 hours Treatable: Yes Mortality Rate: 65%
Dosage/Symptoms: Dosage should be .001 microgram per kilogram of body weight. Symptoms include weakness, dizziness, dry throat and mouth, blurred vision, progessive weakening of muscles, interuption of neurotransmission leading to paralysis and abrupt respiratory failure followed by death. Treatable only if antitoxin is administered early. Vaccine is also available. |
Agent Name: Ricin (derived from castor beans) What Agent Causes: Ricin poisoning Time to Affect: 1-5 hours Length: 3 days Treatable: No Mortality Rate: Very high
Dosage/Symptoms: The dosage for Ricin is 3 to 5 micrograms for every 1 kilogram of body weight. Symptoms include rapid weakness, fever, cough, fluid build up in lungs and respiratory distress. No antitoxin or vaccine is currently available. |
This is only a short list of the biological agents used in warfare. There are a lot more that we know about, and even more that we don't. Also there will always be terrorists or insane power hungry dictators trying to come up with more and more ways to kill somebody.
Although scientists began experimenting with chemical agents long before World War I, most chemical agents were first introduced during this combat. These were devastating weapons that were especially harmful to foot soldiers. Many deaths occurred that could have been prevented using a simple gas mask. These weapons generated tremendous fear and loathing for the enemy. They also caused the need for massive medical support teams and evacuation plans. Use of these weapons during WWI created the stage for future efforts to control the use of chemical weapons including those described below.
NERVE AGENTS
Nerve agents acquired their name because they affect the transmission of nerve impulses in the nervous system. All nerve agents belong chemically to the group of organo-phosphate compounds. Nerve agents are highly toxic and have rapid effects both when absorbed through skin and via respiration. Easily manufactured by means of fairly simple chemical techniques, nerve agents have dominated the chemical warfare scene since World War I, and have been proven the most dangerous of chemical weapons.
Table 1 - Nerve agents
Agent |
Mode of Action |
Rate of Action |
Form when Disseminated |
Lethal Amounts |
Effects |
Tabun |
Inhalation |
effects occur with in 10-15 minutes |
Liquid or Gas |
150mg-min m-3 |
-irrated eyes, nose, and pupils -drooling -defecation -loss of over all body control -death occurs when victim goes in comatose and suffocates |
Sarin |
Inhalation |
immediate |
Gas (Vapor) |
.5 milligram |
affects the transmission of nerve impulses in the nervous syste |
BLOOD AGENTS
Blood agents get their name by interfering with cellular respiration. This causes the victim to suffocate. Death soon follows if victim goes untreated. The symptoms of blood agents are very similar to those of carbon-monoxide have a bitter almond smell or taste. Although blood agents are non-persistent, in cold weather they can contaminate an area for days or weeks.
Table 2 - Blood agents
Agent |
Mode of Action |
Rate of Action |
Form when Dissemin-ated |
Commer-cial Uses |
Mechanism of Action |
Effects |
Hydrogen Cyanide |
Inhalation |
lower con- concentra-tions can be tolerated for an hour, while higher amounts can take effect immediately |
Gas (Vapor) |
- a method of inflicting capital punishment - fumigation |
The cyanide ion interfere with an enzyme that is essential for oxidative pro- cess within cells. The central nervous system is susceptible . |
- asphyxiation - violent convulsions - cardiac failure |
Cyanogen Chloride |
Inhalation |
Symptoms of lethal amounts can be observed with in 10-20 seconds |
Gas (Vapor) |
NA |
similar to those of hydrogen cyanide, but irrates eyes, lungs and upper respiratory track |
- eyes, nose, and throat irritation - coughing - tearing |
BLISTER AGENTS
Blister agents, also known as Vesicant agents, work by causing injury and irritation to eyes, lungs, and causing burns or lesions on the skin. Obviously the reasoning behind the term "Blister" agents is evident. Exposure to one of these agents causes immediate respiratory problems, vomiting, the stripping of mucous membrane, large fluid filled blisters, and if exposure was high enough, the filling of the lungs with mucous causing death from suffocation. Death from blister agents usually occurs 4-5 weeks after exposure.
Table 3 - Blister agents
Agents |
Mode of Action |
Rate of Action |
From when Disseminated |
Mechanism of Action |
Effects |
Nitrogen Mustard |
Inhalation or skin contact |
Rash occurs within an hour, blisters appear about six hours later |
Gas (Vapor) |
Similar to Mustard Ypresite |
- hair loss - anemia - low platelet count - low lymphocytes count |
Mustard (Ypresite) |
Inhalation or skin contact |
12 hours |
Gas (Vapor) |
Attacks the lungs, eyes, and skin Strong irritant |
- fluid filled blisters - sore eyes - vomiting - internal/ external bleeding - death in 4-5 weeks |
CHOKING AGENTS
Fist used in World War I, choking agents cause death when the lungs become so severely damaged that the person exposed to them can not breath. Choking agents attack lung tissue primarily causing pulmonary edema. Because such a large concentration of choking agents are required to make them effective, they are generally not considered an effective weapon in today's world.
Table 4 - Choking agents
Agent |
Mode of Action |
Rate of Action |
Form when Disseminated |
Mechanism of Action |
Effects |
Phosgene |
Inhalation |
effects usually reach maximum 12-24 hours after exposure |
Gas (Vapor) |
It is suggested that it reacts directly and instantaneously at the alveolar and capillary wall, permitting plasma to flood the alveoli. |
- coughing - choking - vomiting - lachrymation |
Diphosgene |
Inhalation |
symptoms of lethal effects are delayed and are sometimes felt up to 3 hours later |
Gas (Vapor) |
when inhaled fluid builds up in the lungs occurs in the lungs and can lead to death by suffocation |
- coughing - fluid build up - irritation of the mucus membrane |
Chloropicrin |
Inhalation |
irritation occurs in seconds, but lethal effects are prolonged 5-15 minutes |
Gas (Vapor) |
same as phosgene |
- shortness of breath - vomiting - fluid build up |
As it can clearly be observed, these were weapons with devastating effects. But even with the effects so great the knowledge produced by those efforts still befit us today. Some of the chemicals are even useful when used in moderation.
Products: The students were required to make a product representative of their task area as well as write the paper. The following products were prepared for Benchmark I, Part I.

A political cartoon.
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